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Advanced gastric cancer, a very rare complication of Common Variable Immunodeficiency: a case report

Reza Fatemi, Yaghoob Moadab, Shahrokh Mousavi, Mohammadreza Zali




Background: Common Variable Immunodeficiency (CVID) is associated with a broad spectrum of symptoms related to infections, chronic lung diseases, autoimmune diseases, and tumors; however, solid tumors are rare complications of CVID and gastric cancer, specially, has been reported very rarely.

Case Presentation: The present case report describes a 28 years old known case of CVID male, who was referred to us because of chronic diarrhea, weight loss and abdominal pain. He had history of recurrent respiratory infections but first manifestations of his recent problem had appeared six months before the referral as epigastric pain, vomiting, and watery diarrhea.

During his initial workup the patient had undergone partial gastrectomy surgery because of the pyloric stenosis. In early assessment of patient in our center, an ulcerative mass lesion with induration and regidity in body and antrum of stomach was seen during upper GI endoscopy. Endoscopic ultrasound evaluation revealed thickening in body layers, expansion of tumor in 3rd and 4th   layers, and 2-3 perigastric lymphadenopathy. Eventually, undifferentiated adenocarcinoma of the stomach was reported by histologic examination.


Common Variable Immunodeficiency; gastric cancer; solid tumor

DOI: https://doi.org/10.22037/ghfbb.v1i2.28