Influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk: a case-control study in Iran
Gastroenterology and Hepatology from Bed to Bench,
Vol. 5 No. 1 (2012),
25 December 2011
https://doi.org/10.22037/ghfbb.v5i1.223
Abstract
Aim: The purpose of this study was to investigate the possible influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk in Iranian patients.
Background: The promoter polymorphism of COX-2 gene -765G>C has been described to play an important role in many cancers such as gastric cancer.
Patients and methods: We carried out single-nucleotide polymorphism analysis in Iranian samples including 91 patients and 91 control normal using PCR- RFLP technique.
Results: Statistical analysis revealed no significant association between GG, GC and CC genotypes and risk of gastric adenocarcinoma. However differences were considered significant (P=0.043) for female subjects with C carrier genotypes (GC and CC) and gastric adenocarcinoma when compared with male patients (P=0.645) and control groups (P=0.653). Also, there was a statistically significant difference between increasing of age and susceptibility for gastric adenocarcinoma (Odd Ratio = 1.125, 95% CI=1.089-1.162).
Conclusion: These results suggested that Iranian C carrier females can be more susceptible for gastric adenocarcinoma in comparison with control group. Also increasing of age should be considered as a risk factor for this disease.
- Gastric adenocarcinoma
- COX-2 Polymorphism
- PCR-RFLP
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