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An Update on Treatment Options for Primary Sclerosing Cholangitis

Shahrokh Iravani, Arash Dooghaie Moghadam, Niloofar Razavi-Khorasani, Bobak Moazzami, Amirreza Dowlati Beirami, Alireza Mansour-Ghanaei, Keivan Majidzadeh-A, Azim Mehrvar, Alireza Khoshdel, Mohssen Nasiri Toosi, Amir Sadeghi



Primary sclerosing cholangitis is a chronic cholestatic liver disease defined by strictures of the biliary tree that could ultimately lead to liver cirrhosis and cholangiocarcinoma. Although the exact underlying aetiology of this disorder is not fully understood, the pathology is believed to be caused by immune mediated mechanisms. The growing body of evidence suggest several treatment modality that focuses mainly on the inflammation aspect of this disorders. However there is still no consensus regarding the best treatment option for these patients. Thus, the present study aimed to review the current treatment options for patients with Primary sclerosing cholangitis.


Inflammatory bowel disease; Primary sclerosing cholangitis (PSC); Management; Vancomycin; Cholestasis; Cholangitis.


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DOI: https://doi.org/10.22037/ghfbb.v13i2.1793