Aim: Evolution of gene expression change of intestine tissue in celiac patients to find a new molecular prospective of disease is the aim of this study.
Background: Celiac disease (CD) as an autoimmune disease is known as an immune reaction response to the gluten in patients. It is reported that genetic and environmental conditions are important in onset and progress of CD.
Methods: gene expression profiles of intestinal tissue in 12 celiac patients and 12 healthy controls from gene expression omnibus (GEO) were downloaded and verified by boxplot analysis. The significant and selected differentially expressed genes (DEGs) were included protein-protein interaction (PPI) network analysis. The central nodes were identified by network analyzer.
Results: The network was constructed from 161 query DEGs and 50 additional neighbors. GTF2H1, VEGFA, SUMO1, RAD51, MED21, BBP4, LEP, and MAP2K7 as potent hub nodes LRP5, RABGEF1, BCAS2, DYRK1B, AOC3, RABL2A, CRTAP, VEGFA, and SPOPL as potent bottlenecks are introduced as crucial nodes.
Conclusion: Among the crucial DEGs, Vascular endothelial growth factor A (VEGFA) was highlighted as an important biomarker candidate for follow up of celiac patients.
Keywords: Celiac disease, Biomarker, VEGFA, Follow up, Gene.
(Please cite as: Rezaei-Tavirani S, Rostami-Nejad M, Montazar F. Highlighted role of VEGFA in follow up of celiac disease. Gastroenterol Hepatol Bed Bench 2019;12(3):254-259).
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