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Prevalence of helicobacter pylori infection in Sari northern Iran; A population based study

Iradj Maleki, Masoumeh Mohammadpour, Niloufar Zarrinpour, Mohadeseh Khabazi, Reza Ali Mohammadpour
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Abstract

Aim: In this study prevalence rate of Helicobacter pylori and its associated factors have been investigated in urban and rural areas of Sari.

Background: Helicobacter pylori has an important role in gastrointestinal diseases including peptic ulcer and gastric cancer. It is the most common infection in human population worldwide. Hence, the epidemiology of this infection in all parts of the world is of utmost importance.

Methods: We conducted a cross-sectional study on 497 individuals ranging 15-65 years of age in Sari city and its surrounding rural residents. The sampling method was a cluster random sampling multi staged in stratified population by urban and rural areas. Questionnaires for personal and socio-economic data were filled. Blood samples were drawn and kept for analysis (IgG antibody ELISA for Helicobacter pylori). The data was analyzed by SPSS statistical software and Chi-square test and logistic regression were used.

Results: The prevalence of helicobacter infection was 44.5% in the studied population. This prevalence was 41.3% and 47.8% in urban and rural areas, respectively. Just a significant association between the infection and the age of subjects was observed in multiple regression analysis (p=0.001). However, in univariate analysis the level of education was also significantly associated with Helicobacter pylori infection (p=0.015). No other variable was associated with the infection.

Conclusion: The prevalence of helicobacter infection has dropped significantly in the region in comparison with the previous studies during the last 15 years.

Keywords: Helicobacter pylori, Prevalence study, Epidemiology, Iran.

(Please cite as: Maleki I, Mohammadpour M, Zarrinpour N, Khabazi M, Mohammadpour RA. Prevalence of Helicobacter pylori infection in Sari Northern Iran; a population based study. Gastroenterol Hepatol Bed Bench 2019;12(1):31-37).


Keywords

Helicobacter pylori, Prevalence study, Epidemiology, Iran.

References

Marshall B, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984;323:1311-5.

Rostami Nejad M, Rostami K, Yamaoka Y, Mashayekhi R, Molaei M, Dabiri H, et al. Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy. Arch Iran Med. 2011;14:115-8.

Halakou A, Khormali M, Yamrali A, Zandi T. The study of seroepidemiology antibodies against Helicobacter pylori in Izeh, a city of Khozestan province in Iran. J Med Lab 2011;5:51-4.

Miller LC, Kelly N, Tannemaat M, Grand RJ. Serologic prevalence of antibodies to Helicobacter pylori in internationally adopted children. Helicobacter 2003;8:173-8.

Cover T. Helicobacter pylori. Abacterial cause of gastritis, peptic ulcer disease, and gastric cancer. ASM news 1995;61:2126.

Blaser MJ. Not all Helicobacter pylori strains are created equal: should all be eliminated? Lancet 1997;349:1020-2.

Baghaei K, Shokrzadeh L, Jafari F, Dabiri H, Yamaoka Y, Bolfion M, et al. Determination of Helicobacter pylori virulence by analysis of the cag pathogenicity island isolated from Iranian patients. Dig Liver Dis. 2009;41:634-8.

Rostami-Nejad M, Villanacci V, Mashayakhi R, Molaei M, Bassotti G, Zojaji H, et al. Celiac disease and Hp infection association in Iran. Rev Esp Enferm Dig. 2009;101:850-4.

Mahyar A, Tayefe N. Antibody Titration against to H. Pilory in rural and urban children from Ghazvin city. Research in Medical Science 2006;30:213-6.

Rasheed F, Ahmad T, Bilal R. Prevalence and risk factors of Helicobacter pylori infection among Pakistani population. Pak J Med Sci 2012;28:661-5.

Babamahmoodi F, Âjemi AG, kalhor M, Khalilian AR, shfiei GR. A sero epidemiological study of helicobacter pylori infection in Sari in 2001-2002. J Mazandaran Univ Med Sci 2004;14:39-50.

Farhadi A, Bahar A, Kosarian M, Mahdavi MR. A sero epidemiological study of helicobacter pylori infection in students of 7-18 years of age in Sari township during 1999. J Mazandaran Univ Med Sci 2000;10:19-26.

Fani A, Rezaei M, Alizade B, Mirzajani P, Shamsikhan S, Rafeie M, et al. Prevalence of Helicobacter pylori Infection in Arak, Iran during 2011. Govaresh 2014;19:57-62.

Owrang M, Tahmasbpour MI, Imani S, Darzy H, Nejadmoghadam A. Comparison of IgG and IgA Antibodies Titrations against Helicobacter pylori in Urban and Rural Populations in Mazandaran Province. J Fasa Univ Med Sci 2014;4:50-7.

Yazdanpanah K, Rahimi E, Sharifian A, Eishi A. Epidemiology of Helicobacter pylori infection in Kurdistan Province, 2006. SJKU 2009;14:1-8.

Siadat ZKM. The relationship between Helicobacter pylori infection with epidemiological factors and eating habits. Ninth Congress of Nutrition; Tabtiz University of Medical Sciences. 2006.

Zahedi MJ, Darvish-Moghadam S, Atapour M, Hayatbakhsh-Abasi M. Relative frequency of Helicobacter pylori infection in the city of Kerman in 2000. SJKU 2009;9:140-5.

Sayehmiri F, Darvishi Z, Sayehmiri K, Soroush S, Emaneini M, Zarrilli R, et al. A Systematic Review and Meta-Analysis Study to Investigate the Prevalence of Helicobacter pylori and the Sensitivity of its Diagnostic Methods in Iran. Iran Red Crescent Med J 2014;16:e12581.

Hoang TTH, Bengtsson C, Phung DC, Sörberg M, Granström M. Seroprevalence of Helicobacter pylori infection in urban and rural Vietnam. Clin Diagn Lab Immunol 2005;12:81-5.

Sitas F, Forman D, Yarnell J, Burr M, Elwood P, Pedley S, et al. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut 1991;32:25-8.

Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T, et al. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterol 1992;102:760-6.

Graham DY, Adam E, Reddy GT, Agarwal JP, Agarwal R, Evans Jr DJ, et al. Seroepidemiology ofHelicobacter pylori infection in India. Dig Dis Sci 1991;36:1084-8.

Smoak BL, Kelley PW, Taylor DN. Seroprevalence of Helicobacter pylori infections in a cohort of US Army recruits. Am J Epidemiol 1994;139:513-9.




DOI: https://doi.org/10.22037/ghfbb.v0i0.1425