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Detection of asymptomatic celiac disease in two siblings from a mother with non-celiac gluten sensitivity

Umberto Volta, Giacomo Caio, Roberto Manfredini, Roberto De Giorgio




Non-celiac gluten sensitivity and celiac disease are known to be two distinct clinical entities, however, non-celiac gluten sensitivity has been detected in a proportion of first-degree relatives of celiac patients. Herein for the first time we describe the occurrence of asymptomatic celiac disease in two siblings, a girl and a boy, whose mother suffered from a proven non-celiac gluten sensitivity. Both the 12-year old girl and 9-year old boy were positive for anti-endomysial and anti-tissue transglutaminase antibodies of IgA class at a very high and low titer, respectively.  Duodenal biopsy confirmed the diagnosis of active celiac disease (severe villous flattening) in the girl, whereas her brother had Marsh 1 lesion consistent with a potential celiac disease. This case report indicates that antibody screening for celiac disease can be recommended in any symptomatic or asymptomatic first-degree relatives of patients with non-celiac gluten sensitivity.

Keywords: Celiac disease, Non-celiac gluten sensitivity, Screening, Serology, Relatives, Familiarity.

(Please cite as: VoltaU, CaioG, ManfrediniR, De Giorgio R. Detection of asymptomatic celiac disease in two siblings from a mother with non-celiac gluten sensitivity. Gastroenterol Hepatol Bed Bench 2018;11(3):269-272).


celiac disease; non-celiac gluten sensitivity; screening; serology; relatives; familiarity.



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DOI: https://doi.org/10.22037/ghfbb.v0i0.1394