Network analysis of common genes related to esophageal, gastric, and colon cancers

Padina Vaseghi Maghvan, Mostafa Rezaei –Tavirani, Hakimeh Zali, Abdolrahim Nikzamir, Saeed Abdi, Mahsa Khodadoostan, Hamid Asadzadeh-Aghdaei

Abstract


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Aim: The aim of this study is to provide a biomarker panel for esophageal cancer, gastric cancer and colorectal cancer. It can help introduce a few diagnostic biomarker candidates for the three diseases.

Background. Gastrointestinal cancer (GICs) including esophageal cancer, gastric cancer and colorectal cancer is the most common related death in the world which is diagnosed in the final stages and due to heterogeneity of these diseases, the treatments usually are not successful. For this reason, many studies have been conducted to discover predictive biomarkers.

Material and method. In the present study, 507 genes extracted that related to three esophageal cancer, gastric cancer and colon cancer. The network was constructed by Cytoscape software (version 3.4.1) then a main component of the network was analyzed considering centrality parameters including degree, betweenness, closeness and stress. Three clusters of the protein network accompanied with their seed nodes were determined by MCODE application in Cytoscape software. Furthermore, Gene Ontology (GO) analysis of the key genes in combination to the seed nodes is performed.

Result. The network of 17 common differential expressed genes in three esophageal, gastric and colon adenocarcinomas including 1730 nodes and 9188 edges was constructed. Eight crucial genes was determined. Three Clusters of the network was analyzed by GO analysis.

Conclusion. The analyses of common genes of the three cancers showed there are some common crucial genes including TP53, EGFR, MYC, AKT1, CDKN2A, CCND1 and HSP90AA1 which are tightly related to gastrointestinal cancers and can be predictive biomarker candidate for the three cancers.

 

 


Keywords


Keywords: Colon cancer, Gastric cancer, Esophageal cancer, Gene ontology, Biomarker candidate

References


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DOI: http://dx.doi.org/10.22037/ghfbb.v0i0.1212

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GHFBB by Gastroenterology and Liver Diseases Research Institute is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

PISSN: 2008-2258

EISSN: 2008-4234


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