Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer

Miganoosh Simonian, Meysam Mosallayi, Maryam Miraghajani, Awat Feizi, Sharifeh Khosravi, Ahmad Reza Salehi, Deniz Mortazavi, Farideh Saberi, Rasoul Salehi





NFKBIA gene, microRNA, single-nucleotide polymorphism, colorectal cancer


Cunningham D, Atkin W, Lenz HJ, et al. Colorectal cancer. Lancet. 2010 Mar 20;375(9719):1030-47. doi: 10.1016/s0140-6736(10)60353-4.

Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107.

Alwan A. Global status report on noncommunicable diseases 2010. World Health Organization; 2011.

Etemadi A, Sadjadi A, Semnani S, et al. Cancer registry in Iran: a brief overview. Arch Iran Med. 2008 Sep;11(5):577-80.

Chan AT, Giovannucci EL, Meyerhardt JA, et al. Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. Jama. 2005;294(8):914-923. doi:10.1001/jama.294.8.914

Huxley RR, Ansary-Moghaddam A, Clifton P, et al. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int J Cancer. 2009 Jul 1;125(1):171-80. doi: 10.1002/ijc.24343.

von Roon AC, Reese G, Teare J, et al. The risk of cancer in patients with Crohn's disease. Dis Colon Rectum. 2007 Jun;50(6):839-55. doi: 10.1007/s10350-006-0848-z.

Terzić J, Grivennikov S, Karin E, et al. Inflammation and colon cancer. Gastroenterology. 2010;138(6):2101-2114. e5. doi: 10.1053/j.gastro.2010.01.058

Perkins ND. The diverse and complex roles of NF-κB subunits in cancer. Nature Reviews Cancer. 2012;12(2):121-132. doi:10.1038/nrc3204

Biswas DK, Cruz AP, Gansberger E, et al. Epidermal growth factor-induced nuclear factor κB activation: a major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proceedings of the National Academy of Sciences. 2000;97(15):8542-8547. doi: 10.1073/pnas.97.15.8542

Yu HG, Yu LL, Yang Y, et al. Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis. Oncology. 2003;65(1):37-45. doi: 71203.

Zhang P, Wei Q, Li X, et al. A functional insertion/deletion polymorphism in the promoter region of the NFKB1 gene increases susceptibility for prostate cancer. Cancer genetics and cytogenetics. 2009;191(2):73-77. doi: 10.1016/j.cancergencyto.2009.01.017

Lo S-S, Chen J-H, Wu C-W, et al. Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients. Surgery. 2009;145(3):280-285. doi: 10.1016/j.surg.2008.11.001

Kim H-J, Kim K-W, Yu B-P, et al. The effect of age on cyclooxygenase-2 gene expression: NF-κB activation and IκBα degradation. Free Radical Biology and Medicine. 2000;28(5):683-692. doi: 10.1016/S0891-5849(99)00274-9

Aggarwal BB, Takada Y, Shishodia S, et al. Nuclear transcription factor NF-kappa B: role in biology and medicine. Indian journal of experimental biology. 2004;42(4):341-353.

Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. cell. 2004;116(2):281-297. doi: 10.1016/S0092-8674(04)00045-5

Carleton M, Cleary MA, Linsley PS. MicroRNAs and cell cycle regulation. Cell cycle. 2007;6(17):2127-2132. doi: 10.4161/cc.6.17.4641

Cho WC. MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy. The international journal of biochemistry & cell biology. 2010;42(8):1273-1281. doi: 10.1016/j.biocel.2009.12.014

Manikandan M, Munirajan AK. Single nucleotide polymorphisms in microRNA binding sites of oncogenes: implications in cancer and pharmacogenomics. Omics: a journal of integrative biology. 2014;18(2):142-154. 10.1089/omi.2013.0098

Song S, Chen D, Lu J, et al. NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population. PLoS one. 2011;6(6):e21726. doi: 10.1371/journal.pone.0021726

Zhang G-L, Zou Y-F, Feng X-L, et al. Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis. Inflammation Research. 2011;60(1):11-18. doi:10.1007/s00011-010-0216-2

Liu Y, Qiu F, Yang L, et al. Polymorphisms of NFκB1 and IκBα and their synergistic effect on nasopharyngeal carcinoma susceptibility. BioMed research international. 2015;2015. doi: 10.1155/2015/362542

Gao J, Pfeifer D, He L-J, et al. Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations. Scandinavian journal of gastroenterology. 2007;42(3):345-350. doi: 10.1080/00365520600880856

Huang D, Yang L, Liu Y, et al. Functional polymorphisms in NFκB1/IκBα predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. Human genetics. 2013;132(4):451-460. doi: 10.1007/s00439-013-1264-9

Umar M, Upadhyay R, Kumar S, et al. Association of common polymorphisms in TNFA, NFkB1 and NFKBIA with risk and prognosis of esophageal squamous cell carcinoma. PloS one. 2013;8(12):e81999. doi:10.1371/journal.pone.0081999

Osborne J, Lake A, Alexander FE, et al. Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma. International journal of cancer. 2005;116(4):646-651. doi:10.1002/ijc.21036

Han X, Zhang J-j, Yao N, et al. Polymorphisms in NFKB1 and NFKBIA genes modulate the risk of developing prostate cancer among Han Chinese. Medical science monitor: international medical journal of experimental and clinical research. 2015;21:1707. doi: 10.12659/MSM.893471

Oltulu Y, Coskunpinar E, Ozkan G, et al. Investigation of NF-κB1 and NF-κBIA gene polymorphism in non-small cell lung cancer. BioMed research international. 2014;2014. doi: 10.1155/2014/530381

Pallavi S, Anoop K, Showket H, et al. NFKB1/NFKBIa polymorphisms are associated with the progression of cervical carcinoma in HPV-infected postmenopausal women from rural area. Tumor Biology. 2015;36(8):6265-6276. doi: 10.1007/s13277-015-3312-7

Yenmis G, Oner T, Cam C, et al. Association of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Behçet's Disease. Scandinavian journal of immunology. 2015;81(1):81-86. doi: 10.1111/sji.12251

Curran JE, Weinstein SR, Griffiths LR. Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. Cancer letters. 2002;188(1):103-107. doi: 10.1016/S0304-3835(02)00460-3

Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Cancer Research. 1992;52(20):5575-5589.

Giardiello F, Offerhaus G, DuBois R. The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. European Journal of Cancer. 1995;31(7):1071-1076. doi: 10.1016/0959-8049(95)00137-8


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PISSN: 2008-2258

EISSN: 2008-4234


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