Oral squamous cell cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma

Nasibeh Khayyer, Mona Zamanian Azodi, Vahid Mansouri, Mohammad Ghssemi-Broumand, Mostafa Rezaei-Tavirani, Mohammad Hossein Heidari, Majid Rezaei Tavirani



Aim: The aim of this study is to present the oral Squamous Cell Cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma.

Background: Oral squamous cell cancer (OSCC) is a common disease worldwide, with poor prognosis and limited treatment. Thus, introducing molecular markers through network analysis can be helpful.

Methods: STRING database (DB) was applied for network construction through Cytoscape 3.4.0.  Clue GO handled the gene annotation for the retrieved clusters. Eight proteins were indicated to be differential in the network constitution.

Results: The centrality and clustering analysis indicate that TP53 plays an over-significant role in network integrity among eight most central proteins including TP53, AKT1, EGFR, MYC, JUN, CDH1, CCND1, and CTNNB1.  The suggested biomarker set is very similar to the related biomarker panel of esophageal adenocarcinoma.

Conclusion: The ontology analysis implies that the prominent proteins are involved in regulation of smooth muscle cell proliferation, regulation of fibroblast proliferation, and response to UV-A processes.  In conclusion, these proteins and their associated biological processes may be more critical compared to other reported biomarkers for OSCC. Nevertheless, validation studies are required for confirming the pivotal role of potential candidates. Similar biomarker panel of this disease and esophagus adenocarcinoma is corresponded to the origin of the two malignancies.

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DOI: http://dx.doi.org/10.22037/ghfbb.v0i0.1119

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PISSN: 2008-2258

EISSN: 2008-4234


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