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Is treatment of fatty liver effective on reducing carotid intima media thickness: A cohort study

Saeideh Ghaffarifar, Manouchehr Khoshbaten, Fattaneh Dordaei, Maryam Zareh Nahandi, Reza Javad-Rashid, Tahereh Shahnazi




Aim: This study was intended to explore the effect of various drugs used to treat fatty liver on intimal-media thickness in patients with NAFLD.
Background: Nonalcoholic fatty liver disease (NAFLD) is an indicator of a broad spectrum of pathologic disorders, which is characterized with macro vesicular steatosis in the absent of alcohol use. It has a wide range of laboratory, clinical and pathological presentations such as simple steatosis to the diseases like non-alcoholic steatohepatitis, fibrosis, and cirrhosis and hepatocellular cancer.
Methods: In this cross - sectional study, as a part of a 10-year cohort study (from 2007-2017) at Tabriz University of Medical Sciences, a group of 100 patients with NAFLD were studied. They were examined by color doppler sonography of the carotid arteries to detect any carotid intima- media thickness, before and one year after treatment with various drugs. The effect of treatment on right and left carotid intima- media thickness (IMT) was examined by using SPSS. V21.
Results: Over all, 36 (36%) patients were male and 64 (64%) were female. The mean age of the patients was a 43.5±10.3 year, ranging from 16 to 64. The decrease in patients' intima- media thickness in both right and left carotids was statistically significant (P<0.0001).
Conclusion: Treatment of patients with nonalcoholic fatty liver has a significant role in reduction of their carotid intima -media thickness and consequently in reducing cerebrovascular events such as stroke.
Keywords: Carotid, Intima Media thickness; Color Doppler Sonography, Fatty Liver.
(Please cite as: Ghaffarifar S, Khoshbaten M, Dordaei F, Zareh Nahandi M, Javad-Rashid R, Shahnazi T. Is treatment of fatty liver effective on reducing carotid intima media thickness; a cohort study. Gastroenterol Hepatol Bed Bench 2018;11(1):9-14).


Carotid; Intima Media thickness; Color Doppler Sonography; Fatty Liver


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DOI: https://doi.org/10.22037/ghfbb.v0i0.1112