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PAX-5 positive anaplastic large cell lymphoma presenting by dysphagia Case report

Negar Azarpira, Akbar Safaie, Ahmad Monabati, Masudd Hosseinzadeh, Sadat Noori, Maryam Moini, Alireza Rahimi, Tahereh Heidari, Marjan Rahsaz




Anaplastic large cell lymphoma (ALCL) is a distinct pathologic entity with characteristic morphologic, im¬munophenotypic and cytogenetic features.  Obstructive symptoms are rare presentation of ALCL. We report a 16-year-old boy who initially presented with dysphagia. Upper gastrointestinal endoscopy revealed severe stenosis with an infiltrative process starting from 24 cm of incisors in lower esophagus Esophageal mucosal biopsy demonstrated lymphomatous involvement that ancillary tests confirmed the diagnosis of ALCL, ALK (kinase-positive), and PAX5 positive. The patient responded to CHOP-based chemotherapy. This case illustrated an unusual presentation of primary Non Hodgkin lymphoma of esophagus.

Keywords: PAX5, Anaplastic large cell lymphoma, Esophagus, stricture.


PAX5, Anaplastic large cell lymphoma, Esophagus, stricture



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DOI: https://doi.org/10.22037/ghfbb.v0i0.1022