A Survey and Prioritizing of Medicinal Herbs Effective on Memory Improvement in Iranian Traditional Medicine

Reza Mirheidary, Seyed Saeid Esmaeili Saber, Mohammad Reza Shaeiri, Mohammad Gholami Fesharaki



Background and Aim: In recent years, the use of medicinal herbs for memory improvement and the treatment of Alzheimer's disease has been the subject of many medical researches. The aim of this research is study and prioritizing of medicinal herbs enhances memory in Iranian Traditional medicine.
Materials and Methods: First, 33 medicinal Mofradeh (single drug which can be herbal, animal or mineral) derived from the book Canon of Medicine by keywords which were related to enhancing of memory, mind, senses and understanding, effective on amnesia (Nesyan), beneficial for the brain and memory disorder. Then 12 Mofradeh that were herbal and specific for memory improvement more than others were selected from 33 drugs and was searched their impact on memory in books Makhzan al-advieh, al-Havi fi-Alteb, al-Shamel fi-alsenaat altebbiah, Tohfeh-Almomenin, al-Abnieh aan Haghayegh al-advieh. Al-Moetamed fi-al-advieh. Each of Mofradat, obtained special score based on descriptions in books and were prioritized.
Findings: 12 medicinal herbs memory enhancer are respectively: 1- Boswellia sp; 2- Anacardium occidentale; 3- Cyperus rotundus, Zingiber officinalis, Aquilaria malaccensis; 4- Terminalia chebula; 5- Piper elongatum, Phylanthus embolica, Acorus calamus,Brassica nigra; 6- Aloe sp., Rosa damascena oil.
Conclusion: Numerous studies have shown beneficial effects of plants on learning and memory improvement. It seems the survey of effectiveness of medicinal herbs enhancing memory that mentioned specially herbs with more score need to clinical research in healthy people and patients with memory disorder and it helps memory enhancing in healthy people and treatment of patients effectively, if approved.


Please cite this article as: Mirheidary R, Esmaeili Saber SS, Shaeiri MR, Gholami Fesharaki M. A Survey and Prioritizing of Medicinal Herbs Effective on Memory Improvement in Iranian Traditional Medicine. Med Hist J 2018; 10(35): 7-19.

Please cite this article as: Mirheidary R, Esmaeili Saber SS, Shaeiri MR, Gholami Fesharaki M. A Survey and Prioritizing of Medicinal Herbs Effective on Memory Improvement in Iranian Traditional Medicine. Med Hist J 2018; 10(35): 7-19.


Memory; Medicinal Herbs; Iranian Traditional Medicine; Mofradeh; Alzheimer's Disease

Full Text:




Emami M, Hosseini A, Saeedi A, Golbidi D, Reisi P, Alaei H. Effect of red grape juice on learning and passive avoidance memory in rats. J Isfahan Med Sch 2010; 28(104): 1-7.

Atkinson R, Nolen-Hoeksema S. Atkinson & Hilgard's Introduction to Psychology: New York: McGraw-Hill; 2004. p.268-314.

Groth-Marnat G. Handbook of psychological assessment. 49th ed. Tehran: Sokhan Publication; 2003.

Chaghmini M. Ghanooncheh fi Al-Tebb. 1st ed. Tehran: Iran University of Medical Sciences Publication; 2010.

Aminoff MJ, Greenberg D, Simon RP. Clinical Neurology. 1st ed. Tehran: Teimourzadeh Publication; 2016.

Farbood Y, Sarkaki A, Shahrani KM, Saadatfard M. Effect of grape seed extract on improving memory and learning impairment induced by streptozotocin in male rat. Journal of Gorgan University of Medical Sciences 2016; 18(2): 27-34.

Ahvazi A. Kamel al-Senaate al-Tebbiah. 1st ed. Qom: Jalalodin Publication; 2008.

Avicenn H. The Canon of Medicine. Beirut: Darol-Ehia al-Torath al-Arabia Publication; 2008.

Nazem Jahan M. Exire Aazam. Tehran: Iran University of Medical Sciences. Resarch Institute for Islamic & complementary Medicine Publication; 2008.

Ahmadian-Attari MM, Ahmadiani A, Kamalinejad M, Dargahi L, Shirzad M, Mosaddegh M. Treatment of Alzheimer’s disease in Iranian traditional medicine. Iran Red Crescent Med J 2015;17(1): e18052.

Bakhtiyari E, Ahmadian-Attari MM, Salehi P, Khallaghi B, Dargahi L, Mohamed Z, et al. Non-polyphenolic compounds of a specific kind of dried grape (Maviz) inhibit memory impairments induced by beta-amyloid peptide. Nutritional Neuroscience 2017; 20(8): 469-477.

Hajiaghaee R, Akhondzadeh S. Herbal medicine in the treatment of Alzheimer’s disease. Journal of Medicinal Plants 2012; 1(41): 1-7.

Hosseinkhani A, Sahragard A, Namdari A, Zarshenas MM. Botanical Sources for Alzheimer’s: A Review on Reports From Traditional Persian Medicine. American Journal of Alzheimer's Disease & Other Dementias 2017; 32(7): 429-437.

Naseri M. Study of Antileptic Drugs in Iranian Traditional Medicine Iran. Tehran: Shahid Beheshti University of Medical Sciences; 1993.

Mozaffarpur SA, Khodadust M, Shirafkan H, Yousefi M, Mirzapor M. Introducing a model for prioritization of drugs, based on Iranian traditional medicine references. Medical History Journal 2014; 6(19): 11-28.

Gruenwald J, Brendler T, Jaenicke C. PDR for herbal medicines. 4th ed. Boca Raton: Thomson, Reuters; 2008.

Aghili Alavi khorasani M. Makhzan al-Advieh. Tehran: Enghelab-e Eslami Publishing and Educational Organization; 1992.

Avicenn H. The Canon of Medicine. Beirut: Darol-Ehia al-Torath al-Arabia Publication; 2008.

Ebn Nafis Ghareshi A. Al-Shamel fi al-Senaat al-Tebbiah. Tehran: Iran University of Medical Sciences Press; 2008.

Hakim Moemen M. Tohfeh al-Moemenin. Qom: Noore Vahi Publication; 2011.

Heravi AMM. Al-Abniye an Haghayegh al-Adviye. Correction by Bahmanyar A. Tehran: Tehran University; 1967. p.168.

Ghassani Torkamani M. Al-Moetamad fi al-Advieh al-Mofradeh. Beirut: Darol-Kotob al-Belie Publication; 2000.

Razi M. Alhavi fi al-Tebb. Beirut: Darol-Ehia al-Torath al-Arabia Publication; 2001.

Hosseinzadeh H, Ramezani M, Akhtar Y, Ziaei T. Effects Boswellia carterii gum resin fractions on intact memory and hyoscine-induced learning impairments in rats performing the morris water maze task. Journal of Medicinal Plants 2010; 2(34): 95-101.

Tavakkolifar B, Massoudi M, Zarringhalam J. Review on pharmacological activities of gum olibanum. Journal of Medicinal Plants 2009; 4(32): 1-13.

Naderi G, Khalili M, Karimi M, Soltani M. The effect of oral and intraperitoneal administration of Acorus calamus L. extract on learning and memory in male rats. Journal of Medicinal Plants 2010; 2(34): 46-56.

Rabiei Z, Hojjati M, Rafieian-Kopaeia M, Alibabaei Z. Effect of Cyperus rotundus tubers ethanolic extract on learning and memory in animal model of Alzheimer. Biomedicine & Aging Pathology 2013; 3(4): 91-185.

Golechha M, Bhatia J, Singh Arya D. Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice. Journal of Environmental Biology 2012; 33(1): 95-100.

Manyam BV. Dementia in ayurveda. The Journal of Alternative and Complementary Medicine 1999; 5(1): 81-88.

Wattanathorn J, Jittiwat J, Tongun T, Muchimapura S, Ingkaninan K. Zingiber officinale mitigates brain damage and improves memory impairment in focal cerebral ischemic rat. Evid Based Complement Alternat Med 2011; 2011: 429505. Doi: 10.1155/2011/429505.

Qi HS, Liu P, Gao SQ, Diao ZY, Yang LL, Xu J, et al. Inhibitory effect of piperlonguminine/ dihydropiperlonguminine on the production of amyloid beta and APP in SK-N-SH cells. Chin J Physiol 2009; 52(3): 160-168.

Halder S, Mehta AK, Mediratta PK. Aloe vera improves memory and reduces depression in mice. Nutritional Neuroscience 2013; 16(6): 250-254.

Aparna K, Deshpande N, Sowdi S, Guruprasad R. Extraction of Alpha-Amylase Activators and Acetyl-Cholinesterase Inhibitors from Seeds of Brassica Nigra and Screening of It’s Activity on Zebrafish for Treatment of Hypoglycemia and Alzheimer’s Disease. Word Journal of Pharmacy and Pharmacutical Sciences 201; 7(2): 999-1009..

Kiametis AS, Martins JB, Romeiro LA, Gargano R. Acetylcholinesterase inhibitors: modeling potential candidates. International Journal of Quantum Chemistry 2013; 113(10): 1461-1466.

Esfandiary E, Karimipour M, Mardani M, Alaei H, Ghannadian M, Kazemi M, et al. Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer's disease. Journal of Neuroscience Research 2014; 92(4): 517-530.

Bahrani H. Isolation and Characterization of Acetylcholinestrase Inhibitors from Aquilaria Species for Treatment of Alzhimer Disease (Ad). Kuala Lumpur: University of Malaya; 2013.

Shojaii A, Ghods R, abdollahi Fard M. Medicinal herbs in Iranian traditional medicine for learning and memory. African Journal of Traditional, Complementary and Alternative Medicines 2016; 13(2): 199-209.


  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License CC BY-NC 4.0. Copyright © 2016 Medical History JournalAll rights reserved.  All credits and honors to PKP for their OJS.

For Author | Online Submission | About Contact