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Cancer-related fatigue and its association with health-related quality of

Shirin Hasanvand, Tahereh Ashktorab, Zohreh Jafari, Nayereh Salmani, Zeinab Safariyan





Background and aim:

 Fatigue is one of the most common complications and symptoms of cancer. It affects

on people's ability and quality of life and functional status. This study examined Cancer-related fatigue and

 relationship with health-related quality of life and functional status of cancer patients.

 Materials and Methods:

In this corelational descriptive study, 57 cancer patients were selected by

consecutive sampling. Fatigue, quality of life and functional status of patients measured by the Fatigue

 Severity Scale (FSS), FACT–G and Karnofsky Performance Scale. Validity and reliability of questionnaires

 were investigated by content validity and alpha chronbach. Data analysis was done by descriptive statistics

 and Pearson correlation coefficient, T test, Mann-Whitney, Kruskal-Wallis and ANOVA.



The mean fatigue score of samples was 4/36. The overall mean of QoL was 66 (14/65) and 5/89% of

samples had moderate quality of life. Results of functional status showed that most patients (61.4%) were able


to perform normal activity and functional status scores range between 20 to 100.There was significant and


inversely statistical differences between fatigue and quality of life. (r = - 0/69, p <0/000). Functional status

 was significantly and inversely correlated with fatigue (r = - 0 / 58, p <0/000).


 cancer patients experienced moderate fatigue. Considering relationship between fatigue with

quality of life and functional status, it's necessary to be considered action to reduction of fatigue and therefore

 improve of quality of life and functional status of cancer patients.


 Health-related quality of life, fatigue, cancer, cancer, functional status





Health-related quality of life, fatigue, cancer, cancer, functional status


Barsevick A, Dudley W, Beck S(2006).Cancer-related fatigue, depressive symptoms, and functional status: A

mediation model. Nursing Research.55(5) 366-72.

Dagnelie PC, Pijls-JohannesmaMCG,Lambin P, BeijerS,DeRuysscher D, Kempen GIJM(2007). Impact of fatigue

on overall quality of life in lung and breast cancer patients selected for high-dose radiotherapy. Oxford

Journals.Annals of Oncology. 18(5) 940-944.

Darvishpoorkakhaki A Abed SaeediZh,Saeed-o-zakerin M(2010).Tools for measurement of health status and quality

of life of elderly people.Pajouhesh Dar Pezeshki Journal of Reasearch in Medical Sciences. 33(3)


Dodd M. J, Cho M, Bank K. A, Lee J ,QuiveyJ(2008). Correlation of symptoms, quality of life, and functional

status in head and neck cancer patients receiving radiation therapy ± chemotherapy.Journal of Clinical

Oncology.26 (15) 20671[abstract].

DoddM J, Cho MH, Cooper B A, MiaskowskiCh (2010).T he effect of symptom clusters on functional status and

quality of life in women with breast cancer. European Journal of Oncology Nursing. 14(2) 101–110.

Esther Kim JE, Dodd MJ, Aouizerat BE, Jahan T, Miaskowsky C (2009). A review of the prevalence and impact of

multidle symptoms in oncology patients.Journal of Pain and Symptom Management.37 (4) 715-736.

Farajollahi M,Alikhani M, Farmani F, Hosseini F(2003).[Fatigue in cancer patients receiving chemotherapy].Iran

Journal of Nuursing. 16(36)1-7.(Persian).

Ghaffari F, Fotokian Z, Karimi M, Keihanian SH, Karimi H (2009).The relationship between anemia-related fatigue

and quality of life in canceric patients.JQUMS(The Journal of Qazvin University of Medical Sciences). 13(1)34-


Ghanbari A, Momeni M, Rahimi A (2011). [Predictors of performance status in patients with colorectal cancer].

Journal of GuilanUniversity of Medical Sciences. 20(80) 1-9(Persian).

Hassan Pour Dehkordi A, Shaban M (2005).[ Relationship between cancer characteristics and quality of life in the

cancer patients under chemotherapy reffered to selected clinics of Tehran University of medical sciences].

Shahrekord University of Medical Sciences Journal.6(4) 63-71(Persian).

HeydarnejadMS,hassanpourdehkordiA,SolatiDehkordi k (2011).[Factors affecting quality of life in cancer patients

undergiong chemotherapy. African Health Sciences.11(2) 266-270

Karami O, Falahatpisheh F, JahaniHashemi H, Beiraghdar N (2010). Quality of life in cancer patients in Qazvin.

Journal of Qazvin University of Medical Sciences and Health Services.14(3) 80-86 (Persian).

Lilenbaum RC, Cashy J, Hensing TA, young S, Cella D (2008).Prevalence of poor performance status in lung cancer

patients.Journal of Thoracic Oncology. 3(2) 125-129

Luctkar-Flude Mf, Groll Dl, Tranmer Je, Woodend K( 2007). Fatigue and physical activity in older adults with cancer:

Cancer Nursing. 30(5):E35-45.

Mousavi S, AsriA (2003).[ Educational requirements of patients with cancer during chemotherapy and radiotherapy for

their self- care]. Journal of Babol University of Medical Science. (17) 17-20 (Persian).

PakpourA,PanahiD,YekaninejadS,Norozi S (2009).[Assessment of quality of life in patient with esophagus

cancer].Payesh Journal. 8(4)371-378.(Persian).

Rad M,MemariyanR.Aghili M(2002). The effect of the scheduled exercise program on the fatigue of cancer patients

under external Radiotherapy.Sabzevar University of Medical Sciences Journal. 9(4)1-9. (Persian).

Reishtein J (2005). Relationship between symptoms and functional performance in COPD.Research in Nursing &

Health.28(1) 39–47 (abstract).

Rezaei R, Saatsaz S, Haji Hosseini F, SharifniaSh, Nazari R (2011). Quality of life in gynecologic patients before and

after chemotherapy.Journal of Babol University of Medical Sciences.13(4) 78-84(Persian).

Safaee A, Zeighami b, Tabatabaee HR, MoghimiDehkordi B (2008).[ Quality of life and related factors in breast

cancer patients under chemotherapy]. Iranian Journal of Epidemiology. 3 (3,4) 61-66 ( Persian).

Sanchez R, Ballesteros M, Arnold B (2011).Validation of FACT – G scale for evaluating quality of life in cancer

patients. Quality of life Research. 20(1)19-29.

ShahvarughiFarahani A, Azimian M, Fallahpour M, Karimlou M(2013) Evaluation of Reliability and Validity of the

Persian Version of Fatigue Severity Scale (FSS) among Persons with Multiple Sclerosis. Quarterly Journal of

Rehabilitation. 13 (4) 84-91

SolhiM,KhazaeepulM,Abdi N (2008). [Assessment of quality of life in multiple myeloma patients in Iran medical

university in Tehran on 2007.8 th Congress of Hematology and Oncology.

Tulman L, Faweett J (2007). Development of comprehensive inventory of functioning- cancer. Cancer Nursing. 30(3)


Visser MR, Smets EM(1998). Fatigue, depression and quality of life in cancer patients: how are they related?

Supportive Carein Cancer.6(2)101-8(abstract).

Wedding U, Rohring B, Klippstein A, Brix C, Pientka L, Hoffken K (2007). Comorbidity and functional deficits

independently contribute to quality of life before chemotherapy in elderly patients. SupportiveCare inCancer. 15(9)


WangS, Tsai, CH, Chen B, Lin CH, Lin CH (2008). Symptom clusters and relationships to symptom interference with

daily life in Taiwanese lung cancer patients. Journal of Pain and Symptom Management.35(3) 258-266.

Yaghmaei F (2008). [Introducing a new scale for activities of daily living].Journal of Faculty Nursing and Midwifery

of ShahidBeheshti University of Medical Sciences and Health Services.15(50) 3-12 (Persian).

ZakerimoghadamM,ShabanM,KazemnejadA,TavasoliKh (2006).Effect of respiratory exercises on fatigue of patients

with COPD. The Journal of Faculty of Nursing & Midwifery, Tehran University of Medical Sciences (HAYAT).


ZeighamiMohammadiSh, Houshmand P, Jafari F, Esmaily H, Kooshyar MM (2008).[The relationship between anemia

and severity of fatigue and quality of life in cancer patients undergoing chemotherapy]. Scientific Journal of

Hamadan Nursing & Midwifery Faculty. 16(2) 43-49.( Persian)

Zimmermann C Burman D Bandukwala Sh et al (2010) Nurse and physician inter- rater agreement of three

performance status measures in palliative cancer patients. Supportive Care in Cancer. 18(5)609-616

DOI: https://doi.org/10.22037/anm.v24i85.8109