Hematological indices in prolonged menstruation: New roles for blood groups and coagulation factors
Archives of Medical Laboratory Sciences,
Vol. 4 No. 4 (2018),
16 February 2020
https://doi.org/10.22037/amls.v4i4.28130
Abstract
Background: Menorrhagia is the most common type of abnormal uterine bleeding, caused by disruption of hormonal regulation, uterine function or blood clotting. Developing an effective diagnostic strategy will improve patient's quality of life and management. Here we investigated the links between hematological characteristics and prolonged menstruation to estimate the importance of the first line coagulation screening tests in young women .
Materials and Methods: In a case-control design and under supervision of a specialist, 43 cases and 104 age matched controls were selected. Menstrual characteristics were evaluated by a standardized questionnaire distributed to high school and university young students. Hematological indices including first line coagulation screening tests were performed for both groups and statistically assessed.
Result: Statistical analysis showed that prolonged menstrual bleeding is significantly correlated to prolonged bleeding time (p value, 0.01) as well as red blood cell count (p value, 0.04). The O blood group showed the greatest contribution to the bleeding periods longer than 7 days (53.4 %(. Additional coagulation tests revealed one coagulation factor VII deficiency patient.
Conclusion: The results of the present study revealed the importance of menorrhagia management in young women and showed a significant correlation between prolonged menstrual bleeding and blood types . Our study findings also suggest a significant association between prolonged menstruation and bleeding time test, emphasizing on the role of blood coagulation traits in susceptibility to heavy menstrual bleeding.
- Menorrhagia
- Coagulation
- Blood groups
- Hematological traits
How to Cite
References
Rivara A, James AH. Managing Heavy Menstrual Bleeding in Women at Risk of Thrombosis. Clin Obstet Gynecol. 2018 Jun;61(2):250-9. PubMed PMID: 29596075. Epub 2018/03/30.
Mihm M, Gangooly S, Muttukrishna S. The normal menstrual cycle in women. Anim Reprod Sci. 2011 Apr;124(3-4):229-36. PubMed PMID: 20869180. Epub 2010/09/28. eng.
Kamaludin SAN, Zhang XR, Shorey S. Perspectives of women experiencing Menorrhagia: A descriptive qualitative study. J Clin Nurs. 2019 Jul;28(13-14):2659-68. PubMed PMID: 30917403. Epub 2019/03/28.
Deligeoroglou E, Creatsas G. Menstrual disorders. Endocr Dev. 2012;22:160-70. PubMed PMID: 22846527. Epub 2012/08/01. eng.
El-Hemaidi I, Gharaibeh A, Shehata H. Menorrhagia and bleeding disorders. Curr Opin Obstet Gynecol. 2007 Dec;19(6):513-20. PubMed PMID: 18007127. Epub 2007/11/17. eng.
Shahbazi S, Moghaddam-Banaem L, Ekhtesari F, Ala FA. Impact of inherited bleeding disorders on pregnancy and postpartum hemorrhage. Blood Coagul Fibrinolysis. 2012 Oct;23(7):603-7. PubMed PMID: 22821002. Epub 2012/07/24. eng.
American College of O, Gynecologists Committee on Adolescent Health C, American College of O, Gynecologists Committee Gynecologic P. ACOG Committee Opinion No. 451: Von Willebrand disease in women. Obstetrics and gynecology. 2009 Dec;114(6):1439-43. PubMed PMID: 20134302.
Srivaths LV, Zhang QC, Byams VR, Dietrich JE, James AH, Kouides PA, et al. Differences in bleeding phenotype and provider interventions in postmenarchal adolescents when compared to adult women with bleeding disorders and heavy menstrual bleeding. Haemophilia. 2018 Jan;24(1):63-9. PubMed PMID: 28873279. Pubmed Central PMCID: 5937715.
Rothman MS, Wierman ME. Female hypogonadism: evaluation of the hypothalamic-pituitary-ovarian axis. Pituitary. 2008;11(2):163-9. PubMed PMID: 18404388.
Alaqzam TS, Stanley AC, Simpson PM, Flood VH, Menon S. Treatment Modalities in Adolescents Who Present with Heavy Menstrual Bleeding. J Pediatr Adolesc Gynecol. 2018 Oct;31(5):451-8. PubMed PMID: 29524595.
Ahuja SP, Hertweck SP. Overview of bleeding disorders in adolescent females with menorrhagia. J Pediatr Adolesc Gynecol. 2010 Dec;23(6 Suppl):S15-21. PubMed PMID: 20934893.
Zia A, Rajpurkar M. Challenges of diagnosing and managing the adolescent with heavy menstrual bleeding. Thrombosis research. 2016 Jul;143:91-100. PubMed PMID: 27208978.
Halimeh S. Menorrhagia and bleeding disorders in adolescent females. Hamostaseologie. 2012;32(1):45-50. PubMed PMID: 22127528.
Haamid F, Sass AE, Dietrich JE. Heavy Menstrual Bleeding in Adolescents. J Pediatr Adolesc Gynecol. 2017 Jun;30(3):335-40. PubMed PMID: 28108214.
Venkateswaran L, Yee DL. Rare bleeding disorders in young women. J Pediatr Adolesc Gynecol. 2010 Dec;23(6 Suppl):S38-42. PubMed PMID: 20934892.
Lassila R, Holme PA, Landorph A, Petrini P, Onundarson PT, Hillarp A. Nordic Haemophilia Council's practical guidelines on diagnosis and management of von Willebrand disease. Seminars in thrombosis and hemostasis. 2011 Jul;37(5):495-502. PubMed PMID: 22102192.
Bowman ML, James PD. Controversies in the diagnosis of Type 1 von Willebrand disease. International journal of laboratory hematology. 2017 May;39 Suppl 1:61-8. PubMed PMID: 28447419.
James AH. Von Willebrand disease in women: awareness and diagnosis. Thrombosis research. 2009 Nov;124 Suppl 1:S7-10. PubMed PMID: 19944259.
Cooke AG, McCavit TL, Buchanan GR, Powers JM. Iron Deficiency Anemia in Adolescents Who Present with Heavy Menstrual Bleeding. J Pediatr Adolesc Gynecol. 2017 Apr;30(2):247-50. PubMed PMID: 27789349.
Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, et al. Significant gynecological bleeding in women with low von Willebrand factor levels. Blood Adv. 2018 Jul 24;2(14):1784-91. PubMed PMID: 30042144. Pubmed Central PMCID: PMC6058240. Epub 2018/07/26.
Franchini M, Crestani S, Frattini F, Mengoli C, Bonfanti C. Relationship between ABO blood group and bleeding complications in orally anticoagulated patients. J Thromb Haemost. 2012 Aug;10(8):1688-91. PubMed PMID: 22606934. Epub 2012/05/23.
Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications. Thrombosis journal. 2007 Sep 25;5:14. PubMed PMID: 17894864. Pubmed Central PMCID: 2042969.
Gallinaro L, Cattini MG, Sztukowska M, Padrini R, Sartorello F, Pontara E, et al. A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor. Blood. 2008 Apr 1;111(7):3540-5. PubMed PMID: 18245665. Epub 2008/02/05. eng.
Bharati KP, Prashanth UR. Von Willebrand disease: an overview. Indian journal of pharmaceutical sciences. 2011 Jan;73(1):7-16. PubMed PMID: 22131616. Pubmed Central PMCID: 3224412.
Ali-Saleh M, Lavie O, Abramov Y. Evaluation of blood type as a potential risk factor for early postpartum hemorrhage. PLoS One. 2019;14(4):e0214840. PubMed PMID: 30947286. Pubmed Central PMCID: PMC6448868. Epub 2019/04/05.
Powers JM, Stanek JR, Srivaths L, Haamid FW, O'Brien SH. Hematologic Considerations and Management of Adolescent Girls with Heavy Menstrual Bleeding and Anemia in US Children's Hospitals. J Pediatr Adolesc Gynecol. 2018 Oct;31(5):446-50. PubMed PMID: 29940313.
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