Relation between third trimester urinary iodine concentrations and newborn thyrotrophic hormone
Archives of Medical Laboratory Sciences,
Vol. 1 No. 3 (2015),
20 December 2015
https://doi.org/10.22037/amls.v1i3.10562
Abstract
Background: The aim of the study was to evaluate the third trimester urinary iodine excretion and to assess its relation with newborns thyroid function.
Materials and Methods: A total of 208 healthy third trimester pregnant women without previous history of thyroid disease were included in the study. Urinary iodine levels of mothers were measured and neonatal TSH levels were screened on the 3- 5th day following birth.
Results: The median urinary iodine level in the mothers was 50μg/L. According to WHO criteria for iodine status:14.9%, 34.1% and 49.6% had severe, moderate and mild iodine deficiency, respectively, and only 1.4%, had the adequate iodine intake . In 6 neonate (2.8%) who their TSH level were between 5- 10 IU/ml, nobody had criteria for congenital hypothyroidism at recall visit (15th day). Our results showed the reverse relation between mean Neonatal TSH levels and mother’s third trimester iodine level (r= -0.19, p=0.006).
Conclusion: Although all of mothers included in this study stated that they were using iodized salt, iodine deficiency was frequent . There was also a significant relation between mean neonatal TSH levels and mother’s third trimester iodine urinary level.
- Pregnancy
- Iodine status
- Newborn
- Thyroid function
How to Cite
References
Qian M, Wang D, Watkins WE, Gebski V, Yan YQ, Li M, Chen ZP. The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr.2005; 14:32–42.
Tai M.The devastating consequence of iodine deficiency.Southeast Asian J Trop Med Public Health 1997; 28:75–77.
Santiago-Fernandez P, Torres-Barahona R, Muela-Martinez JA, Rojo-Martinez G, Garcia-Fuentes E, Garriga MJ, Leon AG, Soriguer F. Intelligence quotient and iodine intake: a cross-sectional study in children. J ClinEndocrinolMetab2004; 89:3851–3857.
Davison, JM, Dunlop, W. Renal hemodynamics and tubular function in normal human pregnancy. Kidney Int.1980; 18:152.
Zimmerman MB. The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. Thyroid 2007; 17:829–835.
The Public Health Committee of the American Thyroid Association. Iodine supplementation for pregnancy and lactation—United States and Canada: recommendations of the American Thyroid Association.Thyroid.2006; 16:949–951.
Li M, Eastman CJ, Waite KV, Ma G, Zacharin MR, Topliss DJ, Harding PE, Walsh JP, Ward LC, Mortimer RH, Mackenzie EJ, Byth K, Doyle Z. Are Australian children iodine deficient? Results of the Australian National Iodine Nutrition Study. Med J Aust.2006; 184:165–169.
Andersson M, Aeberli I, Wüst N, Piacenza AM, Bucher T, Henschen I, Haldimann M, Zimmermann MB. The Swiss iodized salt program provides adequate iodine for school children and pregnant women, but weaning infants not receiving iodine-containing complementary foods as well as their mothers are iodine deficient. J Clin Endocrinol Metab.2010; 95:5217–5224.
Perrine CG, Herrick K, Serdula MK, Sullivan KM. Some subgroups of reproductive age women in the United States may be at risk for iodine deficiency. J Nutr2010; 140:1489–1494.
Hiéronimus MS, Bec-Roche M , Ferrari P, Chevalier N , Fénichel P, and Brucker-Davis F, “Iodine status and thyroid function of 330pregnant women from Nice area assessed during the second part of pregnancy,” Annalesd' Endocrinologie, 2009;70: 218–224.
Ordookhani A, Pearce EN, Hedayati M, Mirmiran P, Salimi S, Azizi F, Braverman LE .Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran. Clin Endocrinol (Oxf). 2007;67(2):175-9.
G. Stilwell, P. J. Reynolds, V. Parameswaran, L. Blizzard, T. M. Greenaway, and J. R. Burgess, “The influence of gestational stage on urinary iodine excretion in pregnancy,” The Journal of Clinical Endocrinology & Metabolism.2008; 93: 1737–1742.
Ainy E, Ordookhani A, Hedayati M, Azizi F. Assessment of intertrimester and seasonal variations of urinary iodine concentration during pregnancy in an iodine-replete area. Clin Endocrinol (Oxf) 2007; 67:577–581.
Elnagar B, Eltom A, Wide L, Gebre-Medhin M, Karlsson FA. Iodine status, thyroid function and pregnancy: study of Swedish and Sudanese women. Eur J Clin Nutr1998;52:351–355.
Brander L, Als C, Buess H, Haldimann F, et al. Urinary iodine concentration during pregnancy in an area of unstable dietary iodine intake in Switzerland. J Endocrinol Invest.2003; 26:389–396.
Alvarez-Pedrerol M, Guxens M, Mendez M, Canet Y, et al. Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. Eur J Endocrinol 2009; 160:423–429.
WHO /UNICEF/ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination, a guide for programme managers. 3rd ed. Geneva: World Health Organization Pres
Zimmermann MB.Iodine deficiency. Endocr Rev 2009;30:376-408.
Delange F. Iodine deficiency as a cause of brain damage. Postgrad Med J 2001;77: 217-220.
Nishiyama S, Mikeda T, Okada T, Nakamura K, Kotani T, Hishinuma A. Transient hypothyroidism or persistent hyperthyrotropinemia in neonates born to mothers with excessive iodine intake. Thyroid 2004; 14:1077-1083.
Tahirovic H, Toromanovic A, Grbic S, Bogdanovic G, Fatusic Z, Gnat D. Maternal and neonatal urinary iodine excretion and neonatal TSH in relation to use of antiseptic during caesarean section in an iodine sufficient area. J Pediatr Endocrinol Metab 2009; 22:1145-1149.
Amouzegar A, Azizi F. Variations of urinary iodine during the first trimester
of pregnancy in an iodine-replete area. Comparison with non-pregnant women. HORMONES 2013, 12(1):111-118
Burgi H, Bangerter B, Siebenhuhner L. High day-to-day variability of urinary iodine excretion despite almost universal salt iodization in Switzerland. In: Geertman RM, editor, World Salt Symposium, Vol. 2; Amsterdam; Elsevier: 2000:961-3.
Andersen S, Pedersen KM, Pedersen IB, Laurberg P. Variations in urinary iodine excretion and thyroid function. A 1-year study in healthy men. Eur J Endocrinol 2001; 144: 461-5.
Busnardo B, Nacamulli D, Zambonin L, Mian C, Piccolo M, Girelli ME.Restricted intra individual urinary iodine concentration variability in nonfasting subjects. Eur J Clin Nutr 2006; 60: 421-5.
- Abstract Viewed: 84 times
- PDF Downloaded: 32 times