Materials and Methods: In this study, 72 patients, 48 female and 24 male were selected. Serum Cystatin C and serum Creatinine were assayed, using enzyme-linked immunosorbent assay (ELISA) and routine methods, respectively. Glomerular filtration rate (eGFR) was estimated by Cockcroft and Gault formula. Receiver operating characteristics (ROC) analysis was adopted to evaluate diagnostic accuracy of serum Cystatin C and serum Creatinine.
Results: Using Pearson's Correlation Coefficient analysis among Creatinine, Cystatin C and eGFR showed Serum Cystatin C was better than Creatinine. The sensitivity, specificity and AUC for Serum Cystatin C were 0.88, 0.70 and 0.85, and for Serum Creatinine, they were 0.60, 0.80 and 0.68 respectively.
Conclusion: Our results showed that in early stages of CKD, Cystatin C is a more accurate biomarker for kidney function than Creatinine
Levey, A.S., et al., Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). 2005. 67(6): p. 2089-2100.
Levey, A.S., L.A. Inker, and J.J.J. Coresh, Chronic kidney disease in older people. 2015. 314(6): p. 557-558.
Yamagata, K., et al., Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study. 2007. 71(2): p. 159-166.
Abebe, S.M., et al., Prevalence and associated factors of hypertension: a crossectional community based study in Northwest Ethiopia. 2015. 10(4): p. e0125210.
Braun, L., et al., High burden and unmet patient needs in chronic kidney disease. 2012. 5: p. 151.
Mula-Abed, W.-A.S., K. Al Rasadi, and D.J.O.m.j. Al-Riyami, Estimated glomerular filtration rate (eGFR): a serum creatinine-based test for the detection of chronic kidney disease and its impact on clinical practice. 2012. 27(2): p. 108.
Lee, S.H., et al., Cystatin C as a predictive marker of renal dysfunction and mid-term outcomes following off-pump coronary artery bypass grafting. 2015. 101(19): p. 1562-1568.
Faraji, M.A.H., et al., Serum Cystatin C as an Endogenous Marker of Renal Function in Patients with Chronic Kidney Disease (CKD). 2017. 4(1): p. 3-12.
Pan, Y., et al., A Meta-analysis on diagnostic value of serum cystatin C and creatinine for the evaluation of glomerular filtration function in renal transplant patients. 2014. 14(4): p. 1025-1035.