Cell Therapy and Tissue Engineering in Bone Defect Reconstruction; A Review

Shahrokh Khoshsirat, Maryam Sadat Khoramgah, Aliasghar Keramatinia, Somayeh Niknazar, Shahram Darabi, Foozhan Tahmasebinia, Hassan Peyvandi, Hojjat-Allah Abbaszadeh

Abstract


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Background: Extensive research on bone tissue engineering as a novel therapeutic approach to design and fabricate suitable scaffolds is in progress to overcome the limitations of conventional bone repair techniques. In recent years, tissue engineering and remedial medicine have come up with the strategy of designing, fabricating, and optimizing synthetic and natural scaffolds containing cells and growth factors to facilitate the direct and indirect mechanisms of bone tissue repair in the body. Based on many studies, cellular source, cell medium condition, and biological scaffolds are critical factors in bone defect repair in the field of tissue engineering.

Aim: In this review, we focus on the combination of mesenchymal cells derived from the human adipose tissue, stem cell-to-bone differentiation medium, and biocompatible polyvinyl alcohol-graphene oxide scaffolds in bone lesion repair to gain a better understanding of each factor. This would, in turn, help us design and develop optimal therapeutic approaches for bone repair and regeneration. 

Conclusion: The combination of mesenchymal cells and biocompatible scaffolds proved promising in the process of bone lesion repair.

Keywords


Bone defect; Cell therapy; Tissue engineering

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References


Agarwal R, Garcia AJ. Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair. Advanced drug delivery reviews. 2015 Nov 1;94:53-62.

H. Shegarfi, O. Reikeras, Review article: Bone transplantation and immune response, J. Orthop. Surg. (Hong Kong) 17 (2009) 206-211.

Y. Fillingham, J. Jacobs, Bone grafts and their substitutes, Bone Joint J. 98-B (2016) 6–9.doi: 10.1302/0301-620X.98B.36350.

W. Zhang, Y. Zhu, J. Li, Q. Guo, J. Peng, S. Liu, J. Yang, Y. Wang, Cell-Derived Extracellular Matrix: Basic Characteristics and Current Applications in Orthopedic Tissue Engineering, Tissue Eng. Part B Rev. 22 (2016) 1-15. DOI:10.1089/ten.teb.2015.0290.

Livia Roseti, Valentina Parisi, Mauro Petretta, Carola Cavallo, Giovanna Desando, Isabella Bartolotti, Brunella Grigolo, Scaffolds for Bone Tissue Engineering: State of the art and new perspectives, Materials Science & Engineering C (2017), DOI: 10.1016/j.msec.2017.05.017

A. Atala, F.K. Kasper, A.G. Mikos, Engineering complex tissues, Sci. Transl. Med. 4 (2012)160rv12.doi: 10.1126/scitranslmed.3004890.

G. Bouet, D. Marchat, M. Cruel, L. Malaval, L. Vico, In Vitro Three-Dimensional Bone Tissue Models: From Cells to Controlled and Dynamic Environment, Tissue Eng. Part B Rev. 21 (2015) 133-56. DOI: 10.1089/ten.TEB.2013.0682.

Mizuno H, Tobita M, Uysal AC. Concise review: adipose‐derived stem cells as a novel tool for future regenerative medicine. Stem cells. 2012 May 1;30(5):804-10.

Peyvandi AA, Roozbahany NA, Peyvandi H, Abbaszadeh HA, Majdinasab N, Faridan M, Niknazar S. Critical role of SDF-1/CXCR4 signaling pathway in stem cell homing in the deafened rat cochlea after acoustic trauma. Neural regeneration research. 2018 Jan;13(1):154.

Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279–4295.

Karimfar MH, Peyvandi A, Noorozian M, Ahmadi Roozbahani N, Mastery Farahani R, Khoramgah MS, Azimi H, Bahadori Monfared A, Abbaszadeh HA. Repressing of SOX6 and SOX9 in situ chondrogenic differentiation of rat bone marrow stromal cells. Anatomical Sciences Journal. 2015 May 15;12(2):75-82.Khoramgah MS, Azimi H, Bahadori Monfared A, Abbaszadeh HA. Repressing of SOX6 and SOX9 in situ chondrogenic differentiation of rat bone marrow stromal cells. Anatomical Sciences Journal. 2015 May 15;12(2):75-82.

Peyvandi AA, Abbaszadeh HA, Roozbahany NA, Pourbakht A, Khoshsirat S, Niri HH, Peyvandi H, Niknazar S. Deferoxamine promotes mesenchymal stem cell homing in noise‐induced injured cochlea through PI 3K/AKT pathway. Cell proliferation. 2018 Apr;51(2):e12434

Wu S, Liu X, Yeung KW, Liu C, Yang X. Biomimetic porous scaffolds for bone tissue engineering. Materials Science and Engineering: R: Reports. 2014 Jun 30;80:1-36.

Schieker M, Seitz H, Drosse I, Seitz S, Mutschler W. Biomaterials as scaffold for bone tissue engineering. European journal of trauma. 2006 Apr 1;32(2):114-24.

Schäffler A, Büchler C. Concise review: adipose tissue‐derived stromal cells—basic and clinical implications for novel cell‐based therapies. Stem cells. 2007 Apr 1;25(4):818-27.

Sefati N, Abbaszadeh H, Fadaei Fathabady F, Abdolahifar MA, Khoramgah M, et al. The Combined Effects of Mesenchymal Stem Cell Conditioned Media and Low-Level Laser on Stereological and Biomechanical Parameter in Hypothyroidism Rat Model. J Lasers Med Sci. 2018;9(4):243-8.

Sefati N, Norouzian M, Abbaszadeh HA, Abdollahifar MA, Amini A, Bagheri M, Aryan A, Fathabady FF. Effects of bone marrow mesenchymal stem cells-conditioned medium on tibial partial osteotomy model of fracture healing in hypothyroidism rats. Iranian biomedical journal. 2018 Mar;22(2):90.

Knippenberg M, Helder MN, Zandieh Doulabi B, Semeins CM, Wuisman PI, Klein-Nulend J. Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress on osteogenic stimulation. Tissue engineering. 2005 Nov 1;11(11-12):1780-8.

Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, Van Wijnen AJ, Stein JL, Stein GS. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Critical Reviews™ in Eukaryotic Gene Expression. 2004;14(1&2).

Nakagami H, Morishita R, Maeda K, Kikuchi Y, Ogihara T, Kaneda Y. Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. Journal of atherosclerosis and thrombosis. 2006;13(2):77-81.

Nakagami H, Maeda K, Morishita R, Iguchi S, Nishikawa T, Takami Y, Kikuchi Y, Saito Y, Tamai K, Ogihara T, Kaneda Y. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue–derived stromal cells. Arteriosclerosis, thrombosis, and vascular biology. 2005 Dec 1;25(12):2542-7.

Rehman J, Traktuev D, Li J et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292–98.

Cao Y, Sun Z, Liao L, Meng Y, Han Q, Zhao RC. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochemical and biophysical research communications. 2005 Jul 1;332(2):370-9.

Li RH, Wozney JM. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol 2001;19:255–65.

Lee HS, Cho HH, Kim HK, Bae YC, Baik HS, Jung JS. Tbx3, a transcriptional factor, involves in proliferation and osteogenic differentiation of human adipose stromal cells. Molecular and cellular biochemistry. 2007 Feb 1;296(1-2):129-36.

Quarto N, Longaker MT. FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state. Tissue Eng 2006;12:1405–1418.

Jeong WK, Oh SH, Lee JH, Im GI. Repair of osteochondral defects with a construct of mesenchymal stem cells and a polydioxanone/poly (vinyl alcohol) scaffold. Biotechnology and applied biochemistry. 2008 Feb 1;49(2):155-64.

Bose S, Roy M, Bandyopadhyay A. Recent advances in bone tissue engineering scaffolds. Trends in biotechnology. 2012 Oct 31;30(10):546-54.

Baker MI, Walsh SP, Schwartz Z, Boyan BD. A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2012 Jul 1;100(5):1451-7.

Nkhwa S, Lauriaga KF, Kemal E, Deb S. Poly (vinyl alcohol): physical approaches to designing biomaterials for biomedical applications. InConference Papers in Science 2014 (Vol. 2014). Hindawi.

Lin HL, Liu YF, Yu TL, Liu WH, Rwei SP. Light scattering and viscoelasticity study of poly (vinyl alcohol)–borax aqueous solutions and gels. Polymer. 2005 Jul 11;46(15):5541-9.

Ochiai H, Fujino Y, Tadokoro Y, Murakami I. Polyelectrolyte behavior of poly (vinyl alcohol) in aqueous borax solutions. Polymer Journal. 1982 May 1;14(5):423-6.

Ochiai H, Fukushima S, Fujikawa M, Yamamura H. Mechanical and thermal properties of poly (vinyl alcohol) crosslinked by borax. Polymer Journal. 1976 Jan 1;8(1):131-3.

Han J, Lei T, Wu Q. High-water-content mouldable polyvinyl alcohol-borax hydrogels reinforced by well-dispersed cellulose nanoparticles: Dynamic rheological properties and hydrogel formation mechanism. Carbohydrate polymers. 2014 Feb 15;102:306-16.

Sreedhar B, Sairam M, Chattopadhyay DK, Rathnam PA, Rao DV. Thermal, mechanical, and surface characterization of starch–poly (vinyl alcohol) blends and borax‐crosslinked films. Journal of Applied Polymer Science. 2005 May 15;96(4):1313-22.

Karancsi OL, Bratu EA. The Polytetrafluoroethylene (PTFE) and Collagen Membranes in Bone Grafting for Dental Implants. material plastic. 2016 Sep 1;53(3):537-41.Dubey N, Bentini R, Islam I, Cao T, Castro Neto AH, Rosa V. Graphene: a versatile carbon-based material for bone tissue engineering. Stem cells international. 2015 Jun 1;2015.

Ionita M, Crica LE, Tiainen H, Haugen HJ, Vasile E, Dinescu S, Costache M, Iovu H. Gelatin–poly (vinyl alcohol) porous biocomposites reinforced with graphene oxide as biomaterials. Journal of Materials Chemistry B. 2016;4(2):282-91.

Asran AS, Henning S, Michler GH. Polyvinyl alcohol–collagen–hydroxyapatite biocomposite nanofibrous scaffold: mimicking the key features of natural bone at the nanoscale level. Polymer. 2010 Feb 15;51(4):868-76.

Qu D, Li J, Li Y, Khadka A, Zuo Y, Wang H, Liu Y, Cheng L. Ectopic osteochondral formation of biomimetic porous PVA‐n‐HA/PA6 bilayered scaffold and BMSCs construct in rabbit. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2011 Jan 1;96(1):9-15.

Nitzsche H, Lochmann A, Metz H, Hauser A, Syrowatka F, Hempel E, Müller T, Thurn‐Albrecht T, Mäder K. Fabrication and characterization of a biomimetic composite scaffold for bone defect repair. Journal of Biomedical Materials Research Part A. 2010 Jul 1;94(1):298-307.

Zhang L, Wang Z, Xu C, Li Y, Gao J, Wang W, Liu Y. High strength graphene oxide/polyvinyl alcohol composite hydrogels. Journal of Materials Chemistry. 2011;21(28):10399-406.

Qi YY, Tai ZX, Sun DF, Chen JT, Ma HB, Yan XB, Liu B, Xue QJ. Fabrication and characterization of poly (vinyl alcohol)/graphene oxide nanofibrous biocomposite scaffolds. Journal of Applied Polymer Science. 2013 Feb 5;127(3):1885-94.

Depan D, Girase B, Shah JS, Misra RD. Structure–process–property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds. Acta biomaterialia. 2011 Sep 30;7(9):3432-45.

Lee WC, Lim CH, Shi H, Tang LA, Wang Y, Lim CT, Loh KP. Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide. ACS nano. 2011 Jul 29;5(9):7334-41.

Wang C, Li Y, Ding G, Xie X, Jiang M. Preparation and characterization of graphene oxide/poly (vinyl alcohol) composite nanofibers via electrospinning. Journal of Applied Polymer Science. 2013 Feb 15;127(4):3026-32.

Chahal S, Hussain FS, Yusoff MB. Characterization of modified cellulose (MC)/poly (vinyl alcohol) electrospun nanofibers for bone tissue engineering. Procedia Engineering. 2013 Jan 1;53:683-8.

Pandele AM, Ionita M, Crica L, Dinescu S, Costache M, Iovu H. Synthesis, characterization, and in vitro studies of graphene oxide/chitosan–polyvinyl alcohol films. Carbohydrate polymers. 2014 Feb 15;102:813-20.




DOI: https://doi.org/10.22037/orlfps.v5i2.28005

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