The Impact of Adenotonsillectomy on Mean Platelet Volume in Adenotonsillar Hypertrophy

Shima Arastou, Alireza Shahraki, Mahboobeh Karimi Galugahi, Mahtab Rabbani Anari, Nader Akbari Dilmaghani



Background: Chronic adenotonsillar hypertrophy which causes airway obstruction and obstructive sleep apnea is the most common indication for adenotonsillectomy in children. Obstructive sleep apnea is almost always associated with adenotonsillar hypertrophy in this age group. Mean platelet volume (MPV) is an indicator of the platelet size. Platelet size reflects the platelet function and activation. Larger platelets have denser granules and higher thrombosis potential. So higher MPV levels are correlated with higher platelet activity and inflammation intensity. Increased platelet activity has a great role in atherosclerosis, ischemic heart disease and cardiovascular morbidity and mortality. Purpose: The aim of this study is to evaluate the MPV level in patients who underwent adenotonsillectomy. Methods: In this longitudinal study, 37 patients with chronic adentonsillar hypertrophy who underwent adenotonsillectomy were enrolled. MPV levels before and 3 weeks after surgery were recorded and compared with paired comparison analysis. The significance level was less than 0.05. Results: MPV levels were 8.7 ±0.9 and 8.2±1.2 fL, before and after adenotonsillectomy, respectively. A statistically significant decrease was noted in MPV levels following surgery (P=0.022). Conclusion: MPV levels of the patients with adenotonsillar hypertrophy significantly decreased postoperatively. These results demonstrate that MPV level changes can be reversed and treated by adenotonsillectomy.


Adenotonsillar hypertrophy, Adenotonsillectmy, Mean platelet volume (MPV).

Full Text:




Shirley WP, Woolley A, Wiatrak BJ. Pharyngitis and adenotonsillar disease. In: Flint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT, et al. (Eds.), Cummings’ Otolaryngology Head and Neck Surgery. Fifth ed. Philadelphia: Elsevier Mosby; 2010: 2782-2802.

Kottke-Marchant K1, Corcoran G. The laboratory diagnosis of platelet disorders, an algorithmic approach. Arch Pathol Lab Med. 2002; 126(2): 133-46.

Tuncel T1, Uysal P, Hocaoglu AB, Erge DO, Karaman O, Uzuner N. Change of mean platelet volume values in asthmatic children as an inflammatory marker. Allergol Immunopathol (Madr). 2012; 40(2): 104-7.

Tsiara S1, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost. 2003; 9(3): 177-90.

Kaya MG1, Yarlioglues M, Gunebakmaz O, Gunturk E, Inanc T, Dogan A, et al. Platelet activation and inflammatory response in patients with non-dipper hypertension. Atherosclerosis. 2010 Mar; 209(1): 278-82.

Endler G1, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2002; 117(2): 399-404.

Bath P1, Algert C, Chapman N, Neal B; PROGRESS Collaborative Group. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke. 2004; 35(3): 622-6.

Varol E1, Ozturk O, Gonca T, Has M, Ozaydin M, Erdogan D, et al. Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest. 2010; 70(7): 497-502.

Slavka G1, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol. 2011; 31(5): 1215-8.

Ulasli SS1, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume as inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn. 2012; 122(6): 284-90.

Varol E, Dogan A, Erdogan D, Ozaydin M, Peker RO. Septoplasty decreases mean platelet volume levels in patients with marked nasal septal deviation. J Craniofac Surg. 2012; 23(6): 1938.

Bath PM1, Butterworth RJ. Platelet size: measurement, physiology and vascular disease, Blood. Blood Coagul Fibrinolysis. 1996; 7(2): 157-61.

Makay B1, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial mediterranean fever. Clin Rheumatol. 2009; 28(8): 975-8.

von Känel R1, Dimsdale JE. Hemostatic alterations in patients with obstructive sleep apnea and the implications for cardiovascular disease. Chest. 2003; 124(5):1956-67.

Sagit M1, Korkmaz F, Kavugudurmaz M, Somdas MA. Impact of septoplasty on mean platelet volume levels in patients with marked nasal septal deviation. J Craniofac Surg. 2012; 23(4): 974-6.

Varol E1, Ozturk O, Yucel H, Gonca T, Has M, Dogan A, et al. The effect of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea. Platelets. 2011; 22(7): 552-6.

Cengiz C1, Erhan Y2, Murat T3, Ercan A4, Ibrahim S5, Ihsan G6, et al. Values of mean platelet volume in patients with chronic tonsillitis and adenoid hypertrophy. Pak J Med Sci. 2013; 29(2): 569-72.



  • There are currently no refbacks.

Creative Commons License
The Journal of Otorhinolaryngology and Facial Plastic Surgery is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.