Cell Therapy Development in Hearing Loss

Navid Ahmady Roozbahany, Somayeh Niknazar

Abstract


395

Since the potential of stem cells (SCs) in treating diseases is superb, it is believed that the use of SCs is a promising therapeutic approach in hearing damage. More than 250 million people of worldwide are born deaf. The deaf hearing generally originate from defect on sensory receptors (hair cells) or nerves associated with them (spiral ganglion neurons). Hair cells in some animals such as fish, amphibians and birds can regenerate or replace by new cells, but damage to the hair cells in mammals are not being replaced through cell division or regeneration in the inner ear. Cell therapy for hearing loss is still several years away, but researches opens up possibilities for restoring hearing in the future. Here we review developments in cell therapy approach in treatment of hearing loss.

Keywords


Hearing loss; Stem Cells; Hair Cell

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References


Kersigo J, Fritzsch B. Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation. Frontiers in aging neuroscience. 2015;7.

Okano T, Kelley MW. Stem Cell Therapy for the Inner Ear Recent Advances and Future Directions. Trends in amplification. 2012;16(1):4-18.

Raphael Y, Altschuler RA. Structure and innervation of the cochlea. Brain research bulletin. 2003;60(5):397-422.

Warchol ME. Sensory regeneration in the vertebrate inner ear: differences at the levels of cells and species. Hearing research. 2011;273(1):72-9.

Li H, Corrales CE, Edge A, Heller S. Stem cells as therapy for hearing loss. Trends in Molecular Medicine. 2004;10(7):309-15.

Brederlau A, Correia AS, Anisimov SV, Elmi M, Paul G, Roybon L, et al. Transplantation of Human Embryonic Stem Cell‐Derived Cells to a Rat Model of Parkinson's Disease: Effect of In Vitro Differentiation on Graft Survival and Teratoma Formation. Stem cells. 2006;24(6):1433-40.

Vija L, Farge D, Gautier J-F, Vexiau P, Dumitrache C, Bourgarit A, et al. Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes. Diabetes & metabolism. 2009;35(2):85-93.

Sugaya K, Alvarez A, Marutle A, Kwak Y, Choumkina E. Stem cell strategies for Alzheimer's disease therapy. Panminerva medica. 2006;48(2):87-96.

Segers VF, Lee RT. Stem-cell therapy for cardiac disease. Nature. 2008;451(7181):937-42.

Roobrouck VD, Ulloa-Montoya F, Verfaillie CM. Self-renewal and differentiation capacity of young and aged stem cells. Experimental cell research. 2008;314(9):1937-44.

Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlström H, et al. Generalized potential of adult neural stem cells. Science. 2000;288(5471):1660-3.

Brignier AC, Gewirtz AM. Embryonic and adult stem cell therapy. Journal of Allergy and Clinical Immunology. 2010;125(2):S336-S44.

Hu Z, Wei D, Johansson CB, Holmström N, Duan M, Frisén J, et al. Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Experimental cell research. 2005;302(1):40-7.

Parker MA, Corliss DA, Gray B, Anderson JK, Bobbin RP, Snyder EY, et al. Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells. Hearing research. 2007;232(1):29-43.

Ronaghi M, Nasr M, Ealy M, Durruthy-Durruthy R, Waldhaus J, Diaz GH, et al. Inner ear hair cell-like cells from human embryonic stem cells. Stem cells and development. 2014;23(11):1275-84.

Koehler KR, Mikosz AM, Molosh AI, Patel D, Hashino E. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature. 2013;500(7461):217-21.

Li H, Liu H, Heller S. Pluripotent stem cells from the adult mouse inner ear. Nature medicine. 2003;9(10):1293-9.

Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben-Arie N, Eatock RA, et al. Math1: an essential gene for the generation of inner ear hair cells. Science. 1999;284(5421):1837-41.

Xiang M, Gan L, Li D, Chen Z-Y, Zhou L, O’Malley BW, et al. Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development. Proceedings of the National Academy of Sciences. 1997;94(17):9445-50.

Chen W, Johnson SL, Marcotti W, Andrews PW, Moore HD, Rivolta MN. Human fetal auditory stem cells can be expanded in vitro and differentiate into functional auditory neurons and hair cell‐like cells. Stem Cells. 2009;27(5):1196-204.

Pasterkamp RJ, De Winter F, Holtmaat AJ, Verhaagen J. Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. The Journal of neuroscience. 1998;18(23):9962-76.

Hildebrand MS, Newton SS, Gubbels SP, Sheffield AM, Kochhar A, de Silva MG, et al. Advances in molecular and cellular therapies for hearing loss. Molecular Therapy. 2008;16(2):224-36.

Vlastarakos PV, Nikolopoulos TP, Tavoulari E, Papacharalambous G, Tzagaroulakis A, Dazert S. Sensory cell regeneration and stem cells: what we have already achieved in the management of deafness. Otology & Neurotology. 2008;29(6):758-68.

Ogita H, Nakagawa T, Sakamoto T, Inaoka T, Ito J. Transplantation of bone marrow-derived neurospheres into guinea pig cochlea. The Laryngoscope. 2010;120(3):576-81.

Doyle KL, Kazda A, Hort Y, McKay SM, Oleskevich S. Differentiation of adult mouse olfactory precursor cells into hair cells in vitro. Stem cells. 2007;25(3):621-7.

Tateya I, Nakagawa T, Iguchi F, Kim TS, Endo T, Yamada S, et al. Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport. 2003;14(13):1677-81.

Iguchi F, Nakagawa T, Tateya I, Kim TS, Endo T, Taniguchi Z, et al. Trophic support of mouse inner ear by neural stem cell transplantation. Neuroreport. 2003;14(1):77-80.

Brigande JV, Heller S. Quo vadis, hair cell regeneration? Nature neuroscience. 2009;12(6):679-85.

Rideout WM, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell. 2002;109(1):17-27.

Björklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IYC, McNaught KSP, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of the National Academy of Sciences. 2002;99(4):2344-9.

Oshima K, Grimm CM, Corrales CE, Senn P, Monedero RM, Géléoc GS, et al. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. Journal of the Association for Research in Otolaryngology. 2007;8(1):18-31.

White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. 2006;441(7096):984-7.

Fujioka M, Okano H, Edge AS. Manipulating cell fate in the cochlea: a feasible therapy for hearing loss. Trends in neurosciences. 2015;38(3):139-44.

Needham K, Minter RL, Shepherd RK, Nayagam BA. Challenges for stem cells to functionally repair the damaged auditory nerve. Expert opinion on biological therapy. 2013;13(1):85-101.

Hardie NA, Shepherd RK. Sensorineural hearing loss during development: morphological and physiological response of the cochlea and auditory brainstem. Hearing research. 1999;128(1):147-65.

Tong M, Brugeaud A, Edge AS. Regenerated synapses between postnatal hair cells and auditory neurons. Journal of the Association for Research in Otolaryngology. 2013;14(3):321-9.

Martinez-Monedero R, Corrales CE, Cuajungco MP, Heller S, Edge AS. Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons. Journal of neurobiology. 2006;66(4):319-31.

Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. European Journal of Neuroscience. 2007;26(11):3016-23.

Matsumoto M, Nakagawa T, Kojima K, Sakamoto T, Fujiyama F, Ito J. Potential of embryonic stem cell-derived neurons for synapse formation with auditory hair cells. Journal of neuroscience research. 2008;86(14):3075-85.

Fu X, Xu Y. Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability. Genome Med. 2012;4(6):55.

Nayagam BA, Edge AS, Needham K, Hyakumura T, Leung J, Nayagam DA, et al. An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants. Stem cells and development. 2012;22(6):901-12.

Nayagam B, Edge A, Dottori M. Stem cellderived sensory progenitors can innervate the early post-natal sensory epithelium in vitro. Proceedings of the Association for Research in Otolaryngology. 2011:8.

Chen W, Jongkamonwiwat N, Abbas L, Eshtan SJ, Johnson SL, Kuhn S, et al. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature. 2012;490(7419):278-82.




DOI: https://doi.org/10.22037/orlfps.v2i2.14323

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